East Stroudsburg is an historic train station built by the Delaware, Lackawanna and Western Railroad in 1856. The station served as the local stop for both East Stroudsburg and Stroudsburg, Pennsylvania. The depot, recently known locally as the Dansbury Depot for the restaurant that used the building, is located on Crystal Street in East Stroudsburg. Service to East Stroudsburg ended on January 6, 1970, when the Erie Lackawanna Railway discontinued the Lake Cities. A proposal is currently in place to extend NJ Transit service to a rebuilt East Stroudsburg station. In spring 2021, Amtrak announced plans for potential New York–Scranton route. It is currently used by some of Steamtown National Historic Site's excursion trains.

The Lake Cities was a passenger train operated by the Erie Railroad and successor Erie Lackawanna Railway between Chicago and Jersey City, New Jersey and then Hoboken, New Jersey.