East Syracuse is an incorporated village and a suburb of the City of Syracuse in eastern Onondaga County, New York, United States. As of the 2020 census, the population was 3,078. It is located immediately east of Syracuse, in the town of DeWitt.

DeWitt is a town in Onondaga County, New York, United States. As of the 2020 census, the population was 26,074. The town is named after major Moses DeWitt, a judge and soldier. An eastern suburb of Syracuse, DeWitt also is the site of most of the campus and all of the academic buildings of Le Moyne College.