The Ecto-1 is a fictional vehicle from the Ghostbusters franchise. It appears in the films Ghostbusters (1984), Ghostbusters II (1989), Ghostbusters (2016), Ghostbusters: Afterlife (2021), Ghostbusters: Frozen Empire (2024), in the animated television series: The Real Ghostbusters and Extreme Ghostbusters, and in the video games Ghostbusters: The Video Game and Ghostbusters: Spirits Unleashed.

The Ghostbusters franchise consists of American supernatural comedies, based on an original concept created by Dan Aykroyd and Harold Ramis in 1984. The plot follows a group of eccentric New York City parapsychologists who investigate and eliminate ghosts, paranormal manifestations, demigods, and demons. The franchise expanded with licensed action figures, books, comics, video games, television series, theme park attractions, and other branded merchandise.