Edmond Santa Fe High School is a public high school located in Edmond, Oklahoma, United States. Founded in 1993, Santa Fe is one of three traditional high schools in the Edmond Public Schools district, along with Edmond Memorial High School and Edmond North High School. The school's mascot is the Wolf and the school colors are forest green and gray.

Edmond is a city in Oklahoma County, Oklahoma, United States. It is a part of the Oklahoma City metropolitan area, located in Central Oklahoma. The population was 94,428 according to the 2020 United States Census, a 16% increase from 2010. making it the 5th most populous city in Oklahoma.