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Electron-transfer dissociation
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Electron-transfer dissociation is a method of fragmenting multiply-charged gaseous macromolecules in a mass spectrometer between the stages of tandem mass spectrometry. Similar to electron-capture dis
An ion trap mass spectrometer with electron transfer dissociation capability
An ion trap mass spectrometer with electron transfer dissociation capability
Top-down proteomics
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Top-down proteomics is a method of protein identification capable of identifying and quantitating unique proteoforms through the analysis of intact proteins. The name is derived from the similar appro
Electron-transfer dissociation
…dissociation (CID), ETD is advantageous for the fragmentation of longer peptides or even entire proteins. This makes the technique important for top-down proteomics. The method was developed by Hunt and coworkers at the University of Virginia. Electron-capture dissociation (ECD) was developed in 1998 to fragment…
Describing the difference between peptide-centric "bottom-up" proteomics workflow and the proteoform-centric "top-down" workflows, Mass Spectrometry-i
Describing the difference between peptide-centric "bottom-up" proteomics workflow and the proteoform-centric "top-down" workflows, Mass Spectrometry-intensive (MSi-TDP) and Integrative (iTDP).