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Emperor Sukō

Emperor Sukō was the third of Emperors of Northern Court during the Period of the Northern and Southern Courts in Japan. According to pre-Meiji scholars, his reign spanned the years from 1348 through 1351, his personal name was Masuhito, but was changed to Okihito. His father was Emperor Kōgon, his predecessor, Emperor Kōmyō was his uncle, the younger brother of Emperor Kōgon. Lady-in-waiting: Niwata Motoko, Niwata Shigemoto’s daughter First son: Imperial Prince Fushimi-no-miya Yoshihito Second son: Imperial Prince Priest Koshin Court Lady: Anfuku-dono-Naishi Consort: Sanjō-no-Tsubone First daughter: Princess Suiho Third son: Imperial Prince Priest Kojo Sukō occupied the Chrysanthemum Throne from 18 November 1348 until 22 November 1351. In 1348, he became Crown Prince. In the same year, he became Northern Emperor upon the abdication of Emperor Kōmyō. Although Emperor Kōgon ruled as cloistered Emperor, the rivalry between Ashikaga Takauji and Ashikaga Tadayoshi began, in 1351, Takauji returned to the allegiance of the Southern Court, forcing Emperor Sukō to abdicate.

This was intended to reunify the Imperial Line. However, the peace soon fell apart, in April 1352, the Southern Dynasty evacuated Kyoto, abducting with them Retired Emperors Emperor Kōgon and Emperor Kōmyō as well as Emperor Sukō and the Crown Prince Tadahito; because of this, Takauji made Emperor Kōgon's second son Imperial Prince Iyahito emperor. Returning to Kyoto in 1357, Emperor Sukō's son Imperial Prince Yoshihito began to work with the Bakufu to be named Crown Prince, but the Bakufu instead decided to make Emperor Go-Kōgon's son Crown Prince instead. In 1398, Emperor Sukō died. But, 30 years after his death, in 1428, his great-grandson Hikohito, as the adopted son of Emperor Shōkō, became Emperor Go-Hanazono, fulfilling Sukō's dearest wish. Sukō is enshrined at the Daikōmyōji no misasagi in Kyoto. Nanboku-chō Southern courtEras as reckoned by legitimate Court ShōheiNanboku-chō Northern courtEras as reckoned by pretender Court Jōwa Kan'ō Emperor Go-Murakami If the current line of the Japanese royal family fails to produce sons it would be Suko's line that would become the main line and most senior of the House of Yamoto in male primogeniture preference.

The head of this line is Fushimi Hiroaki. Emperor of Japan List of Emperors of Japan Imperial cult

Dermatemydidae

The Dermatemydidae are a family of turtles. The family was named by John Edward Gray in 1870, its only extant genus is Dermatemys. †Baptemys Dermatemys †GomphochelysNotomorpha BibliographyRhodin, Anders G. J.. "Turtles of the world, 2011 update: Annotated checklist of taxonomy, synonymy and conservation status". Chelonian Research Monographs. 5. Archived from the original on 2012-01-31. Bourque, J. R.. A.. I.. "A new dermatemydid from the Paleocene-Eocene Thermal Maximum, Willwood Formation, southeastern Bighorn Basin, Wyoming". Journal of Vertebrate Paleontology. 35: e905481. Doi:10.1080/02724634.2014.905481

WNT7B

Protein Wnt-7b is a protein that in humans is encoded by the WNT7B gene. The WNT gene family consists of structurally related genes; these proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, it encodes a protein showing 99% and 91% amino acid identity to the mouse and Xenopus Wnt7A proteins, respectively. Among members of the human WNT family, this protein is most similar to WNT7A protein; this gene may play important roles in the development and progression of gastric cancer, esophageal cancer, pancreatic cancer. Wnt7b is a key paracrine signaling factor secreted by the ureteric epithelium that establishes the cortico-medullary axis of the mammalian kidney. Wnt7b is a signaling protein that plays a crucial role for many developmental processes including placental, eye and bone formation along with kidney development; the primary role of Wnt7b is to establish the cortico-medullary axis of epithelial organization.

The establishment of the cortico-medullary axis plays an essential role for the development of the medullary component of the kidney. Wnt7b regulates orientation of cell divisions in renal medullary collecting duct epithelium, in, the major structure driving renal medulla formation. There are two interstitial regulators. Pod1, p57Kip2 and integrin α3 are three factors; the knockout of Pod1 results in no renal medullary formation while p57Kip2 and Itga3 knockouts resulted in a reduced renal medulla. Removal of Wnt7b activity leads to a failure of medullary development while other aspects of kidney development including ureteric branching, development of the renal cortex, nephrogenesis are unaffected; the absence of renal medulla affects the plane of epithelial cell division along with little proliferative growth of the loop of Henle. Wnt7b null allele will result in fatality due to the diminution of placental function leading to the failure to initiate organogenesis