End-plate potential
Videos
End plate potentials are the voltages which cause depolarization of skeletal muscle fibers caused by neurotransmitters binding to the postsynaptic membrane in the neuromuscular junction. They are call
A sample endplate potential (EPP; an average of 10 single EPPs) is shown at the top, and sample miniature endplate potentials (mEPPs) are shown at the bottom. Note the differences in the scales on the X- and Y-axes. Both are taken from recordings at the mouse neuromuscular junction.
Signal transmission from nerve to muscle at the motor end plate.
Patient with myasthenia gravis showing typical symptom of eyelid droop
Synaptic vesicle
Videos
In a neuron, synaptic vesicles store various neurotransmitters that are released at the synapse. The release is regulated by a voltage-dependent calcium channel. Vesicles are essential for propagating
Primary hippocampal neurons observed at 10 days in vitro by confocal microscopy. In both images neurons are stained with a somatodendritic marker, microtubule associated protein (red). In the right image, synaptic vesicles are stained in green (yellow where the green and red overlap). Scale bar = 25 μm.
A dynamin 1 dynamin 3 and clathrin independent pathway of synaptic vesicle recycling mediated by elife 01621fs 001