Enrique of Malacca, was a Malay member of the Magellan expedition that completed the first circumnavigation of the world in 1519–1522. He was acquired as a slave by the Portuguese explorer Ferdinand Magellan in 1511 at the age of 14 years, probably in the early stages of the capture of Malacca. Although Magellan's will calls him "a native of Malacca", Antonio Pigafetta states that he was a native of Sumatra. Magellan later took him to Europe, where he accompanied the circumnavigation expedition in 1519. According to some historians, it is possible that he could be the first person to circumnavigate the globe and return to his starting point, however, there is no record or source that confirms it.

The Magellan expedition, also known as the Magellan-Elcano expedition, was a 16th-century Spanish expedition planned and led by Portuguese explorer Ferdinand Magellan. One of the most important voyages in the Age of Discovery—and in the history of exploration—its purpose was to cross the Atlantic and Pacific Oceans to open a trade route with the Moluccas, or Spice Islands, in present-day Indonesia. The expedition departed Spain in 1519 and returned there in 1522 led by Spanish navigator Juan Sebastián Elcano, who crossed the Indian Ocean after Magellan's death in the Philippines. Totaling 60,440 km, or 37,560 mi, the nearly three-year voyage achieved the first circumnavigation of Earth in history. It also revealed the vast scale of the Pacific Ocean and proved that ships could sail around the world on a western sea route.