Ephesus is a city in Heard County, Georgia, United States. The city was founded as "Loftin", and was incorporated as "Ephesus" in 1964, after the local church and school, which had been named for the biblical city of Ephesus in present-day Turkey. The population was 427 at the 2010 census.

Heard County is a county located in the west central portion of the U.S. state of Georgia. At the 2020 census, the population was 11,412, down from 11,834 in 2010. The county seat is Franklin. The county was created on December 22, 1830.