The epidermal growth factor receptor is a transmembrane protein that is a receptor for members of the epidermal growth factor family of extracellular protein ligands.
Diagram of the EGF receptor highlighting important domains
1ivo: Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains.
1m14: Tyrosine Kinase Domain from Epidermal Growth Factor Receptor
1m17: Epidermal Growth Factor Receptor tyrosine kinase domain with 4-anilinoquinazoline inhibitor erlotinib
Stanley Cohen (biochemist)
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Stanley Cohen was an American biochemist who, along with Rita Levi-Montalcini, was awarded the Nobel Prize in Physiology or Medicine in 1986 for the isolation of nerve growth factor and the discovery
Epidermal growth factor receptor
…many cancer types, mutations affecting EGFR expression or activity could result in cancer. Epidermal growth factor and its receptor were discovered by Stanley Cohen of Vanderbilt University. Cohen shared the 1986 Nobel Prize in Medicine with Rita Levi-Montalcini for their discovery of growth factors. Deficient…
Cohen in 2007