The province of Epirus was a province of the Roman Empire, covering the region of Ancient Epirus. Rome first annexed the region in 167 BC, in the aftermath of the Third Macedonian War, and initially put the region in the larger Roman province of Macedonia, which at the time covered the whole of the Hellenistic world in mainland Europe. In 27 BC, Epirus and Achaea were separated from Macedonia and grouped into the senatorial province of Achaea, with the exception of its northernmost part, which remained part of the province of Macedonia. Under Emperor Trajan, sometime between 103 and 114 AD, Epirus became a separate province, under a procurator Augusti. The new province extended from the Gulf of Aulon (Vlorë) and the Acroceraunian Mountains in the north to the lower course of the Acheloos River in the south, and included the northern Ionian Islands of Corfu, Lefkada, Ithaca, Cephallonia, and Zakynthos.

Epirus is a geographical and historical region in southeastern Europe, now shared between Greece and Albania. It lies between the Pindus Mountains and the Ionian Sea, stretching from the Bay of Vlorë and the Acroceraunian Mountains in the north to the Ambracian Gulf and the ruined Roman city of Nicopolis in the south. It is currently divided between the region of Epirus in northwestern Greece and the counties of Gjirokastër and Vlorë in southern Albania. The largest city in Epirus is Ioannina, seat of the Greek region of Epirus, with Gjirokastër the largest city in the Albanian part of Epirus.