The Episcopal Diocese of Indianapolis, formerly known as the Episcopal Diocese of Indiana, is a diocese in Province V of the Episcopal Church. It encompasses the southern two-thirds of the state of Indiana. Its see is in Indianapolis, Indiana, at Christ Church Cathedral. According to the diocesan newsletter, the diocese has 10,137 communicants in 49 parishes. The current bishop is Jennifer Baskerville-Burrows, the first African-American woman to serve as diocesan bishop in the Episcopal Church and the first woman to succeed another woman as a diocesan bishop in the Episcopal Church; Catherine Waynick served as bishop of the diocese from 1997 to 2017.

Christ Church Cathedral is the cathedral for the Episcopal Diocese of Indianapolis. Christ Church parish was formally organized in 1837. The present-day church building was erected in 1857 on Monument Circle at the center of downtown Indianapolis to replace the parish's first church built on the same site. Designed by architect William Tinsley, the English Gothic Revival-style structure is the oldest church building in Indianapolis and Marion County, Indiana, that has remained in continuous use. It is also the oldest building on Monument Circle. Christ Church is known for its music, especially its pipe organs, one of which was donated by Ruth Lilly, and its professional Choir of Men and Boys and Girls' Choir. The parish is also known for its community service, including an annual strawberry festival fundraiser and other charitable work. Christ Church Cathedral was added to the National Register of Historic Places on July 10, 1973. It is located in the Washington Street-Monument Circle Historic District.