The Episcopal Diocese of Missouri is the diocese of the Episcopal Church in the United States of America with jurisdiction over 54 counties in eastern Missouri. It has 42 congregations and is in Province 5. Its cathedral, Christ Church Cathedral, is in St. Louis, as are the diocesan offices. The current bishop is Deon K. Johnson.

Daniel Sylvester Tuttle was consecrated a bishop of the Episcopal Church in 1866. His first assignment was as Bishop of Montana, a missionary field that included Montana, Utah, and Idaho.