The Episcopal Diocese of South Carolina (EDOSC), known as The Episcopal Church in South Carolina from January 2013 until September 2019, is a diocese of the Episcopal Church. The diocese covers an area of 24 counties in the eastern part of the U.S. state of South Carolina. The see city is Charleston, home to Grace Church Cathedral and the diocesan headquarters. The western portion of the state forms the Episcopal Diocese of Upper South Carolina. As a diocese of the Episcopal Church, the Diocese of South Carolina is part of the worldwide Anglican Communion and traces its heritage to the beginnings of Christianity.

The Anglican Diocese of South Carolina (ADOSC) is a diocese of the Anglican Church in North America (ACNA). The diocese covers an area of 24 counties in the eastern part of the state of South Carolina. In 2019, it had 18,195 baptized members and 47 parishes. The see city is Charleston, home to the Cathedral of St. Luke and St. Paul.