The Ernest Orlando Lawrence Award was established in 1959 in honor of a scientist who helped elevate American physics to the status of world leader in the field.

Isadore Perlman was an American nuclear chemist noted for his research of Alpha particle decay. The National Academy of Sciences called Perlman "a world leader on the systematics of alpha decay". He was also recognized for his research of nuclear structure of the heavy elements. He was also noted for his isolation of Curium, as well as for fission of tantalum, bismuth, lead, thallium and platinum. Perlman discovered uses of radioactive iodine and phosphorus for medical purposes. He played a key role in Manhattan Project's plutonium production.