Ervin Ramon Santana is a Dominican former professional baseball pitcher. He played in Major League Baseball for the Los Angeles Angels of Anaheim, Kansas City Royals (twice), Atlanta Braves, Minnesota Twins, and Chicago White Sox. Santana is a two-time All-Star, and he threw a no-hitter with the Angels in 2011.

In baseball, a no-hitter or no-hit game is a game in which a team does not record a hit through conventional methods. Major League Baseball (MLB) officially defines a no-hitter as a completed game in which a team that batted in at least nine complete innings recorded no hits. A pitcher who prevents the opposing team from achieving a hit is thereby said to have "thrown a no-hitter". In most cases, no-hitters are recorded by a single pitcher who throws a complete game; one thrown by two or more pitchers is a combined no-hitter.