Yevgeny Sergeyevich Botkin, commonly known as Eugene Botkin, was the court physician since 1908 for Tsar Nicholas II and Tsarina Alexandra. He sometimes treated the Tsarevich Alexei Nikolaevich of Russia for haemophilia-related complications, like in Spala in 1912.

Ipatiev House was a merchant's house in Yekaterinburg where the former Emperor Nicholas II of Russia, his family, and members of his household were murdered in July 1918 following the Bolshevik Revolution. Its name is identical to that of the Ipatiev Monastery in Kostroma, from where the Romanovs came to the throne. As an act for the 60th anniversary of the Russian Revolutions, it was demolished in 1977 by orders of the Politburo to the local soviet government, almost 59 years after the Romanov family murder and 14 years before the dissolution of the Soviet Union itself.