The Euphrates is the longest and one of the most historically important rivers of Western Asia. Together with the Tigris, it is one of the two defining rivers of Mesopotamia. Originating in Turkey, the Euphrates flows through Syria and Iraq to join the Tigris in the Shatt al-Arab in Iraq, which empties into the Persian Gulf.

West Asia, also called Western Asia or Southwest Asia, is the westernmost region of Asia. As defined by most academics, UN bodies and other institutions, the subregion consists of Anatolia, the Arabian Peninsula, Iran, Mesopotamia, the Armenian highlands, the Levant, the island of Cyprus, the Sinai Peninsula and the South Caucasus. The region is separated from Africa by the Isthmus of Suez in Egypt, and separated from Europe by the waterways of the Turkish Straits and the watershed of the Greater Caucasus. Central Asia lies to its northeast, while South Asia lies to its east. Twelve seas surround the region (clockwise): the Aegean Sea, the Sea of Marmara, the Black Sea, the Caspian Sea, the Persian Gulf, the Gulf of Oman, the Arabian Sea, the Gulf of Aden, the Red Sea, the Gulf of Aqaba, the Gulf of Suez, and the Mediterranean Sea. West Asia contains the majority of the similarly defined Middle East. The Middle East is a political term that has changed many times depending on political and historical context while West Asia is a geographical term with more consistency. It excludes most of Egypt and the northwestern part of Turkey, and includes the southern part of the Caucasus.