European route E22 is one of the longest European routes. It has a length of about 5,320 km (3,310 mi). Many of the E-roads have been extended into Asia since the year 2000; the E22 was extended on 24 June 2002.

The international E-road network is a numbering system for roads in Europe developed by the United Nations Economic Commission for Europe (UNECE). The network is numbered from E1 up and its roads cross national borders. It also reaches Central Asian countries like Kyrgyzstan, since they are members of the UNECE.