European route E 50 is an A-type east–west connection across the European continent. It connects the key naval port of Brest in France with Makhachkala, on the Caspian Sea in the Russian republic Dagestan.

The European route E5 is part of the United Nations international E-road network. It is the westernmost north–south "reference road", running from Greenock in Scotland, south through Great Britain and France to Algeciras, Spain. The route is 1,900 miles (3,100 km) long.