The Evansville Museum of Arts, History & Science is a general-interest museum located on the Ohio riverfront in downtown Evansville, Indiana, United States. Founded in 1904, it is one of Southern Indiana's most established and significant cultural institutions, with comprehensive collections in art, history, anthropology and science. It has a permanent collection of over 30,000 objects including fine arts, decorative arts, historic documents and photographs, and anthropologic and natural history artifacts. Also on the museum's campus is the Evansville Museum Transportation Center, featuring Southern Indiana transportation artifacts from the late 19th through the mid-20th centuries. The museum is accredited by the American Alliance of Museums.

Evansville is a city in and the county seat of Vanderburgh County, Indiana, United States. With a population of 118,414 at the 2020 census, it is Indiana's third-most populous city after Indianapolis and Fort Wayne, the most populous city in Southern Indiana, and the 249th-most populous city in the United States. It is the central city of the Evansville metropolitan area, a hub of commercial, medical, and cultural activity of southwestern Indiana and the Illinois–Indiana–Kentucky tri-state area, which is home to over 911,000 people. The 38th parallel north crosses the north side of the city and is marked on Interstate 69 immediately north of its junction with Indiana 62 within the city's east side.