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Evelyn M. Witkin
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Evelyn M. Witkin was an American bacterial geneticist at Cold Spring Harbor Laboratory (1944–1955), SUNY Downstate Medical Center (1955–1971), and Rutgers University (1971–1991). Witkin was considered innovative and inspirational as a scientist, teacher and mentor.
Witkin in 2012
Evelyn M. Witkin receiving the 2002 National Medal for Science from President George W. Bush
Evelyn M. Witkin receiving the 2002 National Medal for Science from President George W. Bush
SOS response
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The SOS response is a global response to DNA damage in which the cell cycle is arrested and DNA repair and mutagenesis are induced. The system involves the RecA protein. The RecA protein, stimulated by single-stranded DNA, is involved in the inactivation of the repressor (LexA) of SOS response genes thereby inducing the response. It is an error-prone repair system that contributes significantly to DNA changes observed in a wide range of species.
The SOS response inhibits septum formation until bacterial DNA can be repaired and is observable as filamentation when cells are examined by microscop
The SOS response inhibits septum formation until bacterial DNA can be repaired and is observable as filamentation when cells are examined by microscopy (top right of image).