The execution of Dennis McGuire occurred on January 16, 2014, at the Southern Ohio Correctional Facility in Lucasville, Ohio, in what was considered to be a botched execution. McGuire was executed via lethal injection using a new combination of untried and untested drugs: midazolam and hydromorphone. During the execution, witnesses reported that McGuire could be seen struggling to breathe, and reportedly gasped loudly while making snorting and choking sounds for at least ten minutes. It took over twenty-five minutes for McGuire to die, in a process that should normally take just over eight minutes.

Capital punishment is a legal penalty in the U.S. state of Ohio, although all executions have been suspended indefinitely by Governor Mike DeWine until a replacement for lethal injection is chosen by the Ohio General Assembly. The last execution in the state was in July 2018, when Robert J. Van Hook was executed via lethal injection for murder.