In psychology and psychotherapy, existential crises are inner conflicts characterized by the impression that life lacks meaning or by confusion about one's personal identity. Existential crises are accompanied by anxiety and stress, often to such a degree that they disturb one's normal functioning in everyday life and lead to depression. This negative attitude towards life and meaning reflects various positions characteristic of the philosophical movement known as existentialism. Synonyms and closely related terms include existential dread, existential vacuum, existential neurosis, and alienation. The various aspects associated with existential crises are sometimes divided into emotional, cognitive, and behavioral components. Emotional components refer to the feelings they provoke, such as emotional pain, despair, helplessness, guilt, anxiety, or loneliness. Cognitive components encompass the problem of meaninglessness, the loss of personal values or spiritual faith, and reflections about one's own mortality. Outwardly, existential crises often express themselves in addictions, anti-social and compulsive behavior.

The meaning of life pertains to the inherent significance or philosophical meaning of living. There is not a definitive answer, and thinking or discourse on the topic is sought in the English language through the question, "What is the meaning of life?". There have been many proposed answers to these questions from many different cultural and ideological backgrounds. The search for life's meaning has produced much philosophical, scientific, theological, and metaphysical speculation throughout history. Different people and cultures believe different things for the answer to this question. Opinions vary on the usefulness of using time and resources in the pursuit of an answer. Excessive pondering can be indicative of, or lead to, an existential crisis.