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Molecular machinery driving exocytosis in neuromediator release. The core SNARE complex is formed by four α-helices contributed by synaptobrevin, synt
Molecular machinery driving exocytosis in neuromediator release. The core SNARE complex is formed by four α-helices contributed by synaptobrevin, syntaxin and SNAP-25, synaptotagmin serves as a calcium sensor and regulates intimately the SNARE zipping.
In the lipid-lined pore theory, both membranes curve toward each other to form the early fusion pore. When the two membranes are brought to a "critica
In the lipid-lined pore theory, both membranes curve toward each other to form the early fusion pore. When the two membranes are brought to a "critical" distance, the lipid head-groups from one membrane insert into the other, creating the basis for the fusion pore.
Schematic drawing illustrating clathrin-mediated (left) and clathrin-independent endocytosis (right) of synaptic vesicle membranes
Schematic drawing illustrating clathrin-mediated (left) and clathrin-independent endocytosis (right) of synaptic vesicle membranes
From left to right: Phagocytosis, Pinocytosis, Receptor-mediated endocytosis.
From left to right: Phagocytosis, Pinocytosis, Receptor-mediated endocytosis.
Stage 1
Stage 1
Stage 2
Stage 2