Expedition 14 was the 14th expedition to the International Space Station (ISS). Commander Michael López-Alegría, and flight engineer Mikhail Tyurin launched from Baikonur Cosmodrome on 18 September 2006, 04:09 UTC, aboard Soyuz TMA-9. They joined Thomas Reiter, who had arrived at the ISS on 6 July 2006 aboard Space Shuttle Discovery during mission STS-121. In December 2006, Discovery mission STS-116 brought Sunita Williams to replace Reiter as the third member of Expedition 14. On 21 April 2007, López-Alegría and Tyurin returned to Earth aboard TMA-9. Landing occurred at 12:31:30 UTC.

Michael López-Alegría is an astronaut, test pilot and commercial astronaut with dual nationality, American and Spanish; a veteran of three Space Shuttle missions and one International Space Station mission. He is known for having performed ten spacewalks so far in his career, presently holding the second longest all-time EVA duration record and having the fifth-longest spaceflight of any American at the length of 215 days; this time was spent on board the ISS from September 18, 2006, to April 21, 2007. López-Alegría commanded Axiom-1, the first ever all-private team of commercial astronaut mission to the International Space Station, which launched on April 8, 2022, and spent just over 17 days in Earth's orbit.