Expedition 54 was the 54th expedition to the International Space Station, which began upon the departure of Soyuz MS-05 on December 14, 2017 and concluded upon the departure of Soyuz MS-06 on February 27, 2018. Alexander Misurkin, Mark Vande Hei and Joseph Acaba were transferred from Expedition 53, with Alexander Misurkin taking the commander role. Transfer of Command from Expedition 54 to Expedition 55 was done on February 26, 2018. Expedition 54 officially ended on February 27, 2018 23:08 UTC, with the undocking of Soyuz MS-06.

Alexander Alexanderovich Misurkin, a major in the Russian Air Force, is a Russian cosmonaut, selected in 2006. He flew aboard Soyuz TMA-08M on 28 March 2013 as his first space mission, and launched on Soyuz MS-06 as his second flight, in 2017. He was commander of the International Space Station for Expedition 54.