FAME Studios is a recording studio located at 603 East Avalon Avenue in Muscle Shoals, Alabama, an area of northern Alabama known as the Shoals. Though small and distant from the main recording locations of the American music industry, FAME has produced many hit records and was instrumental in what came to be known as the Muscle Shoals sound. It was started in the 1950s by Rick Hall, known as the Founder of Muscle Shoals Music. The studio, owned by Hall until his death in 2018, is still actively operating. It was added to the Alabama Register of Landmarks and Heritage on December 15, 1997, and was listed on the National Register of Historic Places in 2016. The 2013 award-winning documentary Muscle Shoals features Rick Hall, the Muscle Shoals Rhythm Section, and the Muscle Shoals sound originally popularized by FAME.

Muscle Shoals is the largest city in Colbert County, Alabama, United States. It is located on the left bank of the Tennessee River in the northern part of the state and, as of the 2010 census, its population was 13,146. The estimated population in 2019 was 14,575.