The FBI's Ten Most Wanted Fugitives during the 2000s is a list, maintained for a sixth decade, of the Ten Most Wanted Fugitives of the United States Federal Bureau of Investigation. At any given time, the FBI is actively searching for 12,000 fugitives. During the 2000s, 36 new fugitives were added to the list. By the close of the decade a total of 494 fugitives had been listed on the Top Ten list, of whom 463 have been captured or located.

Christian Michael Longo is a convicted murderer who killed his wife and three children in Oregon in December 2001.