The Fall Line Freeway is a 215-mile-long (346 km) highway designed to span the width of the U.S. state of Georgia from Columbus at the Alabama state line to Augusta, travelling through several cities including Macon, Fort Valley, Sandersville, and Wrens. Though it is called a freeway, it is composed of both limited-access and high-speed divided highway portions. There are also two segments of the highway that are two lanes, separated by a center turn lane: a brief portion in west-central Washington County and another brief portion in northern Jefferson County. As of August 2018, the Fall Line Freeway is 100% open to traffic. Between August 2017 and July 2018, the highway was completed. The Georgia Department of Transportation (GDOT) announced that the highway was officially signed as SR 540 on September 24, 2018, as the newest state route in the state.

Interstate 75 (I-75) in the US state of Georgia travels north–south along the U.S. Route 41 (US 41) corridor in the central part of the state, traveling through the cities of Valdosta, Macon, and Atlanta. It is also designated—but not signed—as State Route 401 (SR 401).