The seventh season of Family Guy first aired on the Fox network from September 28, 2008, to May 17, 2009, before being released as two DVD box sets and syndicated. The animated television series follows the dysfunctional Griffin family, who reside in the fictional town of Quahog, in the U.S. state of Rhode Island. The show features the voices of series creator Seth MacFarlane, Alex Borstein, Seth Green, and Mila Kunis in the roles of the Griffin family.

"The Man with Two Brians" is the fifth episode in the seventh season and the 115th episode overall of the American animated television series Family Guy. It premiered on Fox in the United States on November 9, 2008. The episode centers on anthropomorphic dog Brian after he is injured during a stunt being enacted by his owner, Peter, after he watches Jackass with his friends. The family comes to realize that Brian may be getting too old, so Peter brings home a new, optimistic dog. Brian is prompted to leave when his family begins to favor New Brian over him.