Fateh Khan Barakzai or Wazir Fateh Khan or simply, Fateh Khan, was Wazir of the Durrani Empire during the reign of Mahmud Shah Durrani until his torture and execution at the hands of Kamran Shah Durrani, the son of the ruler of the Durrani Empire, and Mahmud Shah Durrani, and other prominent conspirators such as Ata Mohammad Khan. Fateh Khan was of the Barakzai tribe, and his death caused the enmity of his tribe, leading to his tribe revolting and the eventual deposition of Mahmud Shah Durrani.

Emir Dost Mohammad Khan Barakzai, nicknamed the Amir-i Kabir, was the founder of the Barakzai dynasty and one of the prominent rulers of Afghanistan during the First Anglo-Afghan War. With the decline of the Durrani dynasty, he became the Emir of Afghanistan in 1826. An ethnic Pashtun, he belonged to the Barakzai tribe. He was the 11th son of Payendah Khan, chief of the Barakzai Pashtuns, who was killed in 1799 by King Zaman Shah Durrani.