Fayetteville–Manlius High School is a comprehensive New York public high school on East Seneca Turnpike in the Town of Manlius, serving grades 9–12 in the Fayetteville-Manlius Central School District. It is the only high school in the district, and is the successor to both Wellwood Middle School and Eagle Hill Middle School. The school is governed under the authority of the New York State Education Department, whose standardized examinations are designed and administered by the Board of Regents of the University of the State of New York.

Manlius is a town to the east of Syracuse in Onondaga County. As of the 2020 Census, the population was 33,712, making it the third largest suburb in metropolitan Syracuse. In 2005, the town was ranked 98th on CNN's list of Best Places to Live.