The Federal Reserve Bank of Kansas City is located in Kansas City, Missouri and covers the 10th District of the Federal Reserve, which includes Colorado, Kansas, Nebraska, Oklahoma, Wyoming, and portions of western Missouri and northern New Mexico. It is second only to the Federal Reserve Bank of San Francisco in size of geographic area served. Missouri is the only state with two main Federal Reserve Banks; the other is located in St. Louis.

Downtown Kansas City is the central business district (CBD) of Kansas City, Missouri and the Kansas City metropolitan area which contains 3.8% of the area's employment. It is between the Missouri River in the north, to 31st Street in the south; and from the Kansas–Missouri state line eastward to Bruce R. Watkins Drive as defined by the Downtown Council of Kansas City; the 2010 Greater Downtown Area Plan formulated by the City of Kansas City defines the Greater Downtown Area to be the city limits of North Kansas City and Missouri to the north, the Kansas–Missouri state line to the west, 31st Street to the south and Woodland Avenue to the east. However, the definition used by the Downtown Council is the most commonly accepted.