The Fifth Avenue Hotel was a luxury hotel located in Manhattan, New York City from 1859 to 1908. It had an entire block of frontage between 23rd Street and 24th Street, at the southwest corner of Madison Square.

Madison Square is a public square formed by the intersection of Fifth Avenue and Broadway at 23rd Street in the New York City borough of Manhattan. The square was named for Founding Father James Madison, fourth President of the United States. The focus of the square is Madison Square Park, a 6.2-acre (2.5-hectare) public park, which is bounded on the east by Madison Avenue ; on the south by 23rd Street; on the north by 26th Street; and on the west by Fifth Avenue and Broadway as they cross.