First Avenue is a north-south thoroughfare on the East Side of the New York City borough of Manhattan, running from Houston Street northbound to 127th Street. At 125th Street, most traffic continues onto the Willis Avenue Bridge over the Harlem River, which continues into the Bronx. South of Houston Street, the roadway continues as Allen Street south to Division Street. Traffic on First Avenue runs northbound (uptown) only.

Houston Street is a major east–west thoroughfare in Lower Manhattan in New York City, United States. It runs the full width of the island of Manhattan, from FDR Drive along the East River in the east to the West Side Highway along the Hudson River in the west. The street is divided into west and east sections by Broadway.