Following his victory in legislative elections held on 25 January 2015, the newly elected Prime Minister Alexis Tsipras appointed a new cabinet to succeed the cabinet of Antonis Samaras, his predecessor. A significant reshuffle took place on 17 July 2015.

The Cabinet of Antonis Samaras succeeded the Caretaker Cabinet of Panagiotis Pikrammenos after the repeated legislative elections in May and June 2012. It was sworn in on Thursday, 21 June 2012. The former ministries of Shipping, Tourism and Macedonia and Thrace were re-established. The junior coalition partners, PASOK and DIMAR, chose to take a limited role in the cabinet, preferring to be represented by party officials and independent technocrats instead of MPs. Vassilis Rapanos, the prime minister's first choice for finance minister, fell ill before being sworn in, and tendered his resignation on 25 June. Yannis Stournaras was then chosen as the new finance minister on 26 June, and sworn in on 5 July.