The first cabinet of Thabo Mbeki was the cabinet of the government of South Africa from 18 June 1999 until 29 April 2004.

Thabo Mvuyelwa Mbeki is a South African politician who served as the second president of South Africa from 14 June 1999 to 24 September 2008, when he resigned at the request of his party, the African National Congress (ANC). Before that, he was deputy president under Nelson Mandela from 1994 to 1999.