The first deputy premier of the Soviet Union was the deputy head of government of the Union of Soviet Socialist Republics (USSR). Despite the title, the office was not always held by a single individual. The office bore three different titles throughout its existence: First Deputy Chairman of the Council of People's Commissars (1923–1946), First Deputy Chairman of the Council of Ministers (1946–1991), and First Deputy Prime Minister of the Soviet Union (1991). The term "first deputy premier" was used by outside commentators to describe the office of first deputy head of government.

The Premier of the Soviet Union was the head of government of the Union of Soviet Socialist Republics (USSR). Twelve individuals held the post. Among the most known are Vladimir Lenin and Joseph Stalin.