The first deputy premier of the Soviet Union was the deputy head of government of the Union of Soviet Socialist Republics (USSR). Despite the title, the office was not always held by a single individual. The office bore three different titles throughout its existence: First Deputy Chairman of the Council of People's Commissars (1923–1946), First Deputy Chairman of the Council of Ministers (1946–1991), and First Deputy Prime Minister of the Soviet Union (1991). The term "first deputy premier" was used by outside commentators to describe the office of first deputy head of government.

Kirill Trofimovich Mazurov was a Soviet partisan, politician, and one of the leaders of the Belarusian resistance during World War II who governed the Byelorussian Soviet Socialist Republic as First Secretary of the Communist Party of Byelorussia from 1956 until 1965, when he became a member of the Politburo of the CPSU.