The First Presbyterian Church, known as "Old First", is a church located at 48 Fifth Avenue between West 11th and 12th Streets in the Greenwich Village neighborhood of Manhattan, New York City. It was built in 1844–1846, and designed by Joseph C. Wells in the Gothic Revival style. The south transept of the building was added in 1893–1894, and was designed by the firm of McKim, Mead & White. The church complex, which includes a parish house – now referred to as the "South Wing" – on West 11th Street and a church house on West 12th Street designed by Edgar Tafel, is located within the Greenwich Village Historic District.

Joseph Collins Wells (1814–1860) was an English-born architect who practiced in New York City from 1839 to 1860. He was a founding member of the American Institute of Architects, and several of his works have been listed on the National Register of Historic Places. Two of his works, the Henry C. Bowen House and the Jonathan Sturges House, have been designated as U.S. National Historic Landmarks. He also designed First Presbyterian Church, a New York City Landmark in Greenwich Village.