First Presbyterian Church and Manse is a historic Presbyterian church located at West Madison Street and Park Avenue in the Mount Vernon-Belvedere neighborhood of Baltimore, Maryland, United States. The church is a rectangular brick building with a central tower flanked by protruding octagonal turrets at each corner. At the north end of the church is a two-story building appearing to be a transept and sharing a common roof with the church, but is separated from the auditorium by a bearing wall. The manse is a three-story stone-faced building. The church was begun about 1854 by Norris G. Starkweather and finished by his assistant Edmund G. Lind around 1873. It is a notable example of Gothic Revival architecture and a landmark in the City of Baltimore.

Edmund George Lind was an English-born American architect, active in Baltimore, Atlanta, and the American south.