Fisk is a small city in Butler County, Southeast Missouri, United States. It is located right along the Butler-Stoddard County line on U.S. Route 60, along the St. Francis River. The population was 312 at the 2020 census.

Butler County is a county located in the southeast Ozark Foothills Region in the U.S. state of Missouri. As of the 2020 Census, the county's population was 42,130. The largest city and county seat is Poplar Bluff. The county was officially organized from Wayne County on February 27, 1849, and is named after former U.S. Representative William O. Butler (D-Kentucky), who was also an unsuccessful candidate for Vice President of the United States. The first meeting in the Butler County Courthouse was held on June 18, 1849.