The flathead catfish, also called by several common names including mudcat or shovelhead cat, is a large species of North American freshwater catfish in the family Ictaluridae. It is the only species of the genus Pylodictis. Ranging from the lower Great Lakes region to northern Mexico, it has been widely introduced and is an invasive species in some areas. The closest living relative of the flathead catfish is the much smaller widemouth blindcat, Satan eurystomus.

The Ictaluridae, sometimes called ictalurids, are a family of catfish native to North America, where they are an important food source and sometimes fished for sport. The family includes about 51 species, some commonly known as bullheads, madtoms, channel catfish, and blue catfish.