Flora & Ulysses is a 2021 American superhero comedy-drama film directed by Lena Khan from a screenplay by Brad Copeland. It is based on the children's novel of the same name by Kate DiCamillo. The film stars Matilda Lawler, Alyson Hannigan, Ben Schwartz, Anna Deavere Smith, Danny Pudi, Benjamin Evan Ainsworth, Janeane Garofalo, and Kate Micucci while John Kassir provides the vocal effects of Ulysses.

Katrina Elizabeth DiCamillo is an American children's fiction author. She has published over 25 novels, including Because of Winn-Dixie, The Tiger Rising, The Tale of Despereaux, The Miraculous Journey of Edward Tulane, The Magician's Elephant, the Mercy Watson series, and Flora & Ulysses. Her books have sold around 37 million copies. Four have been developed into films and two have been adapted into musical settings. Her works have won various awards; The Tale of Despereaux and Flora & Ulysses won the Newbery Medal, making DiCamillo one of six authors to have won two Newbery Medals.