Florence is a city in, and the county seat of, Lauderdale County, Alabama, United States, in the state's northwestern corner, and had a population of 40,184 in the 2020 census. Florence is located along the Tennessee River and is home to the University of North Alabama, the oldest public college in the state, which makes Florence a college town. Florence is located about 70 miles west of Huntsville, Alabama, via US-72.

Lauderdale County is a county located in the northwestern corner of the U.S. state of Alabama. At the 2020 census the population was 93,564. Its county seat is Florence. Its name is in honor of Colonel James Lauderdale, of Tennessee. Lauderdale is part of the Florence-Muscle Shoals, AL Metropolitan Statistical Area, also known as "The Shoals".