The City of Florence is a statutory city located in Fremont County, Colorado, United States. The city population was 3,822 at the 2020 United States Census. Florence is a part of the Cañon City, CO Micropolitan Statistical Area and the Front Range Urban Corridor.

Fremont County is a county located in the U.S. state of Colorado. As of the 2020 census, the population was 48,939. The county seat is Cañon City. The county is named for 19th-century explorer and presidential candidate John C. Frémont.