Florence is a city in Boone County, Kentucky, United States, part of the Cincinnati metropolitan area. The population was 31,946 at the 2020 census, making it the second-largest city in Northern Kentucky, the eighth-largest city in Kentucky and the state's largest that is not a county seat. Like all but the state's two largest cities, Florence is a home rule-class city under Kentucky state law.

Boone County is a county located on the Ohio River in the northernmost part of the Commonwealth of Kentucky. As of the 2020 census, the population was 135,968, making it the fourth-most populous county in Kentucky. Its county seat is Burlington. The county was formed in 1798 from a portion of Campbell County. and was named for frontiersman Daniel Boone. Boone County, with Kenton and Campbell Counties, is of the Northern Kentucky metro area, and the Cincinnati-Middletown, OH-KY-IN Metropolitan Statistical Area. It is the location of the Cincinnati/Northern Kentucky International Airport, which serves Cincinnati and the tri-state area.