Florida's Turnpike, designated as unsigned State Road 91, is a controlled-access toll road in the U.S. state of Florida, maintained by Florida's Turnpike Enterprise (FTE). Spanning approximately 309 miles (497 km) along a northwest–southeast axis, the turnpike is in two sections. The SR 91 mainline runs roughly 265 miles (426 km), from its southern terminus at an interchange with Interstate 95 (I-95) in Miami Gardens to an interchange with I-75 in Wildwood at its northern terminus. The Homestead Extension of Florida's Turnpike continues from the southern end of the mainline for another 48 miles (77 km) to US Highway 1 in Florida City. The slogan for the road is "The Less Stressway". The mainline opened in stages between 1957 and 1964, while the extension was completed in 1974. The turnpike runs through Miami, Fort Lauderdale, and West Palm Beach, where it parallels I-95, and through Orlando, where it crosses I-4.

Interstate 75 (I-75) is a part of the Interstate Highway System that runs from the Hialeah–Miami Lakes border, a few miles northwest of Miami, to Sault Ste. Marie in the Upper Peninsula of Michigan. I-75 begins its national northward journey near Miami, running along the western parts of the Miami metropolitan area before traveling westward across Alligator Alley, resuming its northward direction in Naples, running along Florida's Gulf Coast, and passing the cities of Fort Myers, Punta Gorda, Venice, and Sarasota. The freeway passes through the Tampa Bay area before turning inward toward Ocala, Gainesville, and Lake City before leaving the state and entering Georgia. I-75 runs for 471 miles (758 km) in Florida, making it the longest Interstate in the state and also the longest in any state east of the Mississippi River. The Interstate's speed limit is 70 mph (110 km/h) for its entire length in Florida.