Florida is a village in Monroe County, Missouri, United States. It is located at the intersection of Missouri Route 107 and State Route U on the shores of Mark Twain Lake. In 1910 the population was 200, per the census data in the 1911 Cram's World Atlas. As of the 2020 census, however, the reported population was five. The Mark Twain Birthplace State Historic Site is located in Florida, with Mark Twain State Park nearby.

Monroe County is a county in northeast Missouri. As of the 2020 census, the population was 8,666. Its county seat is Paris. It is the birthplace of Mark Twain.