State Road 73, the Wayne Mixson State Highway, is a state highway in northwest Florida that runs through Calhoun and Jackson Counties, although it runs through more of the former county than the latter one. The road is always on the west side of the Chipola River, and is almost entirely two-lanes wide, except with its concurrency with US 90 in Marianna where it is four-lanes wide. It was named in honor of former Florida governor Wayne Mixson.

Calhoun County is a county located in the U.S. state of Florida. As of the 2020 census, the population was 13,648, making it the fifth-least populous county in Florida. Its county seat is Blountstown.